abstract：:By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...

journal_title：Developmental cell

authors： Tanimura N,Liao R,Wilson GM,Dent MR,Cao M,Burstyn JN,Hematti P,Liu X,Zhang Y,Zheng Y,Keles S,Xu J,Coon JJ,Bresnick EH

更新日期：2018-09-10 00:00:00

abstract：:For many years, biologists have focused on the role of Pitx2, expressed on the left side of developing embryos, in governing organ laterality. Here, we identify a different pathway during left-right asymmetry initiated by the right side of the embryo. Surprisingly, this conserved mechanism is orchestrated by the extra...

journal_title：Developmental cell

authors： Sivakumar A,Mahadevan A,Lauer ME,Narvaez RJ,Ramesh S,Demler CM,Souchet NR,Hascall VC,Midura RJ,Garantziotis S,Frank DB,Kimata K,Kurpios NA

更新日期：2018-09-10 00:00:00

abstract：:Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopu...

journal_title：Developmental cell

authors： Zhang M,Chen Y,Xu H,Yang L,Yuan F,Li L,Xu Y,Chen Y,Zhang C,Lin G

更新日期：2018-08-20 00:00:00

abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

journal_title：Developmental cell

authors： Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

更新日期：2018-08-20 00:00:00

abstract：:Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...

journal_title：Developmental cell

authors： Roovers EF,Kaaij LJT,Redl S,Bronkhorst AW,Wiebrands K,de Jesus Domingues AM,Huang HY,Han CT,Riemer S,Dosch R,Salvenmoser W,Grün D,Butter F,van Oudenaarden A,Ketting RF

更新日期：2018-08-06 00:00:00

abstract：:Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...

journal_title：Developmental cell

authors： Sugioka K,Bowerman B

更新日期：2018-08-06 00:00:00

abstract：:The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

journal_title：Developmental cell

authors： Wang S,Cebrian C,Schnell S,Gumucio DL

更新日期：2018-07-16 00:00:00

abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...

journal_title：Developmental cell

authors： Wu RS,Lam II,Clay H,Duong DN,Deo RC,Coughlin SR

更新日期：2018-07-02 00:00:00

abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

journal_title：Developmental cell

authors： Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

更新日期：2018-06-18 00:00:00

abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

journal_title：Developmental cell

authors： González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

更新日期：2018-06-04 00:00:00

abstract：:Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...

journal_title：Developmental cell

authors： Haider A,Wei YC,Lim K,Barbosa AD,Liu CH,Weber U,Mlodzik M,Oras K,Collier S,Hussain MM,Dong L,Patel S,Alvarez-Guaita A,Saudek V,Jenkins BJ,Koulman A,Dymond MK,Hardie RC,Siniossoglou S,Savage DB

更新日期：2018-05-21 00:00:00

abstract：:Successive cell divisions during embryonic cleavage create increasingly smaller cells, so intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size, but the mechanisms for this scaling remain unclear. Using live cell imaging, we analyzed spindle scaling during embryo cleavage in t...

journal_title：Developmental cell

authors： Lacroix B,Letort G,Pitayu L,Sallé J,Stefanutti M,Maton G,Ladouceur AM,Canman JC,Maddox PS,Maddox AS,Minc N,Nédélec F,Dumont J

更新日期：2018-05-21 00:00:00

abstract：:Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, a cellular valve for efficient gas exchange, the single symmetric division of an immediate precursor is absolutely essential. Yet, the mechanism governing this event remains unclear. Here we report co...

journal_title：Developmental cell

authors： Han SK,Qi X,Sugihara K,Dang JH,Endo TA,Miller KL,Kim ED,Miura T,Torii KU

更新日期：2018-05-07 00:00:00

abstract：:DNA methylation on N6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global ...

journal_title：Developmental cell

authors： Liang Z,Shen L,Cui X,Bao S,Geng Y,Yu G,Liang F,Xie S,Lu T,Gu X,Yu H

更新日期：2018-05-07 00:00:00

abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

journal_title：Developmental cell

authors： Haag ES,Lo TW

更新日期：2018-04-23 00:00:00

abstract：:Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...

journal_title：Developmental cell

authors： Lyon SM,Kalejta RF

更新日期：2018-04-09 00:00:00

abstract：:piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...

journal_title：Developmental cell

authors： Svendsen JM,Montgomery TA

更新日期：2018-03-26 00:00:00

abstract：:Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decorated with specific cytop...

journal_title：Developmental cell

authors： Sollberger G,Tilley DO,Zychlinsky A

更新日期：2018-03-12 00:00:00

abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...

journal_title：Developmental cell

authors： Zhang Y,Harris TJC

更新日期：2018-02-26 00:00:00

abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...

journal_title：Developmental cell

authors： Hogan BLM

更新日期：2018-02-05 00:00:00

abstract：:Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is th...

journal_title：Developmental cell

authors： Tang Z,Hu Y,Wang Z,Jiang K,Zhan C,Marshall WF,Tang N

更新日期：2018-02-05 00:00:00

abstract：:Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...

journal_title：Developmental cell

authors： Tan R,Foster PJ,Needleman DJ,McKenney RJ

更新日期：2018-01-22 00:00:00

abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...

journal_title：Developmental cell

authors： Patil CK,Denic V

更新日期：2018-01-08 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00

abstract：:The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

journal_title：Developmental cell

authors： Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

更新日期：2017-12-04 00:00:00

abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

journal_title：Developmental cell

authors： Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

更新日期：2017-12-04 00:00:00

abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

journal_title：Developmental cell

authors： Gonzales KAU,Fuchs E

更新日期：2017-11-20 00:00:00

abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

journal_title：Developmental cell

authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

更新日期：2017-11-20 00:00:00

abstract：:The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local ...

journal_title：Developmental cell

authors： Majda M,Grones P,Sintorn IM,Vain T,Milani P,Krupinski P,Zagórska-Marek B,Viotti C,Jönsson H,Mellerowicz EJ,Hamant O,Robert S

更新日期：2017-11-06 00:00:00

abstract：:During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...

journal_title：Developmental cell

authors： Chan CJ,Hiiragi T

更新日期：2017-10-23 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A regio...

journal_title：Developmental cell

authors： Kempf A,Boda E,Kwok JCF,Fritz R,Grande V,Kaelin AM,Ristic Z,Schmandke A,Schmandke A,Tews B,Fawcett JW,Pertz O,Buffo A,Schwab ME

更新日期：2017-10-09 00:00:00

abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

journal_title：Developmental cell

authors： Hogan BM,Schulte-Merker S

更新日期：2017-09-25 00:00:00

abstract：:The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...

journal_title：Developmental cell

authors： Koch F,Scholze M,Wittler L,Schifferl D,Sudheer S,Grote P,Timmermann B,Macura K,Herrmann BG

更新日期：2017-09-11 00:00:00

abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...

journal_title：Developmental cell

authors： Stocker H

更新日期：2017-08-21 00:00:00

abstract：:Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...

journal_title：Developmental cell

authors： Song Y,Marmion RA,Park JO,Biswas D,Rabinowitz JD,Shvartsman SY

更新日期：2017-08-07 00:00:00

abstract：:Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organizatio...

journal_title：Developmental cell

authors： McNulty SM,Sullivan LL,Sullivan BA

更新日期：2017-08-07 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:Specialized areas in the vertebrate retina are critical for high-acuity vision, yet the molecular mechanisms driving the development of high-acuity areas (HAAs) remain largely unknown. In Developmental Cell, da Silva and Cepko (2017) show that restricted degradation of retinoic acid and elevated FGF8 signaling give ri...

journal_title：Developmental cell

authors： Tufford A,Cayouette M

更新日期：2017-07-10 00:00:00

abstract：:Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al. (2017) show that the resemblance is more than superficial: physical principles governing emulsion stability also control lipid droplet nucleation and g...

journal_title：Developmental cell

authors： Roux A,Loewith R

更新日期：2017-06-19 00:00:00